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Poor old Prince William! At Ukmedix News we have written before about his male pattern baldness which is affecting him at an unusually young age of only 25. According to UK news reports it appears that he is finally trying to do something about it and has sent aides who work for him in London to a Harley Street clinic that specialises in male pattern baldness.

While the reports cannot be conclusively confirmed and were denied by a spokesman from Clarence House it is almost certain that Prince William is concerned about his thinning hair and it is extremely unlikely that he has done nothing about it.

The news reports in the United Kingdom said that Prince William had been inquiring about the hair loss drug Propecia and at a glance he would seem to be a perfect candidate for that medication. Propecia is the most successful hair loss medication and is known to help around 80 percent of men with their pattern baldness.

It is bad enough that you suffer from male pattern baldness but for Prince William each time he loses a little bit more hair there is massive speculation in the press which can only add to his anxiety and worry about his hair loss.

Male pattern baldness is not actually an illness but purely a harmless and normal genetic condition however the fact that it causes such distress, anxiety and depression to many men means that it can be classified as something that needs treatment in order to ensure the well being of the patient.

Not everyone sympathises with Prince William as they say he hardly has a bad lot in life being born as an heir to the throne of England, Scotland and Wales and that he lives a life of gilded luxury and privilege. However there is no saying or knowing how Prince William’s confidence will be affected by his hair loss and how he feels about rampant press speculation every time his hair loss is reported.

At Ukmedix News we wish Prince William the best of luck in regrowing his hair with Propecia and hope that the treatment is successful.

I have been reading all about Propecia for several months now. When I heard that Dr. Seiden had a new book about Propecia coming out I could not wait to get my hands on it. I have been watching for this book to hit the Dallas bookstore shelves. I found the book today (4/27/98) and snapped up the very last copy. When I checked out, the Barnes & Noble clerk told me that this book was really “hot”. I understand why after just a few minutes of reading.

What is Propecia? It is the new wonder hair growing drug that has just hit the market after recent FDA approval. It is being hailed as the new and improved Rogaine. There is strong evidence that Propecia really works well at growing hair. The bad news about Propecia…it is not to be used by women of child bearing ages. The other bad news is that is requires a prescription from a physician and could cost from $50-65 a month.

This book is the very first one that discusses Propecia in great detail. It is written by Dr. Othniel J. Seiden who currently practices in Denver, Colorado. He has written 15 other books and has been in medical practice for 35 years. I have always found his books to be well written with lots of good information.

In his latest book on Propecia Dr. Seiden explains everything you could possibly want to know about Propecia.

Finasteride is a competitive and specific inhibitor of Type II 5 alpha-reductase, an intracellular enzyme that converts the androgen testosterone into dihydrotestosterone (DHT). Two distinct isozymes of 5 alpha-reductase are found in mice, rats, monkeys, and humans: Type I and II. Each of these isozymes is differentially expressed in tissues and developmental stages. In humans, Type I 5 alpha-reductase is predominant in the sebaceous glands of most regions of skin, including scalp and liver. Type I 5 alpha-reductase is responsible for approximately one-third of circulating DHT. The Type II 5 alpha-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides and hair follicles as well as liver, and is responsible for two-thirds of circulating DHT.

In humans, the mechanism of action of finasteride is based on its preferential inhibition of the Type II isozyme. Using native tissues (scalp and prostate), in vitro binding studies examining the potential of finasteride to inhibit either isozyme revealed a 100-fold selectivity for the human Type II 5 alpha-reductase over Type I isozyme (IC 50=500 and 4.2 nM for Type I and II, respectively). For both isozymes, the inhibition by finasteride is accompanied by reduction of the inhibitor to dihydrofinasteride and adduct formation with NADP +. The turnover for the enzyme complex is slow (t 1Ä2 approximately 30 days for the Type II enzyme complex and 14 days for the Type I complex).

Finasteride has no affinity for the androgen receptor and has no androgenic, antiandrogenic, estrogenic, antiestrogenic, or progestational effects. Inhibition of Type II 5 alpha-reductase blocks the peripheral conversion of testosterone to DHT, resulting in significant decreases in serum and tissue DHT concentrations. Finasteride produces a rapid reduction in serum DHT concentration, reaching 65% suppression within 24 hours of oral dosing with a 1 mg tablet.

In men with male pattern hair loss (androgenetic alopecia), the balding scalp contains miniaturized hair follicles and increased amounts of DHT compared with hairy scalp. Administration of finasteride decreases scalp and serum DHT concentrations in these men. By this mechanism, finasteride interrupts a key factor in the development of androgenetic alopecia in those patients genetically predisposed.

In a study in 15 healthy male subjects, the mean bioavailability of finasteride 1 mg tablets was 65% (range, 26 to 170%), based on the ratio of AUC relative to a 5 mg i.v. dose infused over 60 minutes. Following the i.v. infusion, mean plasma clearance was 165 mL/min (range, 70 to 279 mL/min) and mean steady-state volume of distribution was 76 L (range, 44 to 96 L). In a separate study, the bioavailability of finasteride was not affected by food.

Approximately 90% of circulating finasteride is bound to plasma proteins. Finasteride has been found to cross the blood-brain barrier.

Due to the drug’s effect on male babies, women should avoid Propecia if there is any chance that they may be pregnant.

Do not use Propecia if it gives you an allergic reaction, or if you’ve ever had an allergic reaction to its chemical twin, Proscar.

Propecia is a pill taken by mouth that is a fairly new and effective treatment for male baldness. An increase in scalp hair count and hair regrowth was seen in over 80% of men for whom it was prescribed. Numerous studies have been done looking at the efficacy of PROPECIA. Overall improvements were seen as quickly as 3 months after starting the medicine. PROPECIA not only led to a decrease in hair loss but also significantly increased the rate of hair regrowth. These effects were maintained for over 2 years with continued PROPECIA therapy.

Propecia should be stored at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Keep this and all medications out of the reach of children.

This drug is taken by mouth. 1 tablet per day. PROPECIA is the brand name for finasteride, which acts to inhibit the conversion of the androgen (male hormone) testosterone into 5-alpha-dihydrotesterone (DHT). In men each hair follicle contains tiny amounts of DHT. As male pattern baldness begins the amount of DHT contained in each follicle increases. PROPECIA through its inhibitory action serves to reverse this process by decreasing the amount of DHT in the hair follicle and in blood.

In clinical studies adverse reactions were noted to be rare and did not affect most men. The most common adverse reaction was decreased libido that appeared to occur in less then 2.0% of men taking this medicine. The problem quickly resolved in all cases upon the discontinuation of the medication.

If you miss a dose, take it as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not “double-up” the dose to catch up.

A study showed that hair grew in thicker, faster, or both.

PROPECIA grows natural hair, not just “peach fuzz.”

At the end of a 4-year study, there was an increase in the weight of hair samples taken from the men who took PROPECIA compared with hair samples taken from the men who took a placebo (sugar pill).

The effectiveness of PROPECIA was demonstrated in studies of men, aged 18 to 41, with mild to moderate hair loss at the top and middle front of the head. There is not sufficient evidence that PROPECIA works for receding hairlines at the temples.

You may see less hair loss in as little as 3 months.

You will need to take PROPECIA for as long as you want to grow or maintain your hair.

If you stop taking PROPECIA, you will likely lose the hair you have gained within 12 months of stopping treatment.

Available data indicate that the level of PROPECIA in the semen of a man taking PROPECIA does not pose a risk to an unborn child. Accordingly, a man can take PROPECIA while conceiving a child with his partner, or have sexual intercourse with his partner if she is already pregnant.

PROPECIA is for the treatment of male pattern hair loss in MEN ONLY and should NOT be used by women or children.

Women who are or may potentially be pregnant must not use PROPECIA and should not handle crushed or broken tablets of PROPECIA because the active ingredient may cause abnormalities of a male baby’s sex organs. If a woman who is pregnant comes into contact with the active ingredient in PROPECIA, a doctor should be consulted. PROPECIA tablets are coated and will prevent contact with the active ingredient during normal handling, provided that the tablets are not broken or crushed.

In clinical studies for PROPECIA, a small number of men experienced certain sexual side effects, such as less desire for sex, difficulty in achieving an erection, or a decrease in the amount of semen. Each of these side effects occurred in less than 2% of men and went away in men who stopped taking PROPECIA because of them.